Runes

Runes are special pickups that spawn in the map and grant various powerful effects when picked up.

Runes begin to spawn at 2:00, and every 2 minutes after (For Mid Wars, Runes spawn at 1:00 then every minute after).
Non-Refreshment runes starts to spawn at 4 minutes.
Runes will not spawn if there already is a non-Refreshment Rune on the map.
The same type of rune cannot spawn twice in a row.
If a Rune spawns where a Refreshment Rune is in, the Refreshment Rune is lost.
Runes can be stored inside an empty Bottle. Simply right-clicking the Rune with an empty Bottle will bottle the Rune.
Once bottled, the Rune can be stored for up to 2 minutes. After 2 minutes, the Rune will be automatically used.
The timer decreases even during death, so if the timer runs out while your Hero is dead, the Rune is effectively wasted.
Once the bottled Rune is used, your Bottle will be filled to full charges.
Runes can also be used to charge an Ioyn Stone. Using an uncharged Ioyn Stone on a major Rune will charge the Ioyn Stone, which can be used to give an ally hero or yourself a weakened effect of the Rune.
Using an Ioyn Stone on a Refreshment Rune will consume it.
Runes can be manually attacked and destroyed.

In Forests of Caldavar, there are two Rune spawn locations in both sides of the river. A Rune will spawn in one of those locations. A Refreshment Rune will also spawn in the other location.
In Mid Wars, there is only one Rune spawn location, close to the middle lane. Since there is only one place a rune can spawn, Refreshment Runes do not spawn in Mid Wars.

Name	description
Double Damage	When activated, gives the Hero a +100% Base Damage buff for 45 seconds.
Haste	When activated, gives the Hero a +10000% Movement Speed and 100% Slow Resistance buff for 30 seconds, effectively setting their Movement Speed to maximum for the duration.
Invisibility	When activated, grants Stealth for 60 seconds with a fade time of 2 seconds. Stealth is broken by attacking or using abilities or items. The fade time is a separate effect from the actual invisibility, and you may perform any action without breaking stealth before the actual invisibility takes place.
Mystic Illusions	When activated, creates 2 Illusions that deal 35% damage and take 300% damage for 75 seconds. Applies Mystic to the affected hero for 45 seconds. Mystic grants 30% Reduced Cooldown and 30% Reduced Mana Costs.
Regeneration	When activated, restores 6% Health and 10% Mana per second for 30 seconds. This effect is dispelled on damage.
Merrick's Rune	Upon picked up, it gives 35 Gold, plus 2 Gold per minute of elapsed game time (excluding the pregame time) and restores 45 Health & 23.333 Mana over 3 seconds that is dispelled on damage, same as a single Bottle use. When bottled, it refills your Bottle to 3/3.